The recent signing of The Securing the U.S. Organ Procurement and Transplantation Network Act marks a new era for organ transplantation in the US. Multiple organizations will now be able to participate in the organ transplant system, ending the monopoly previously held by a single organization. This change brings up questions about how the modernized system will affect wait times for organ transplants and how multiple government contractors will work together to efficiently match donated organs to patients in need. The legislation received bipartisan support and aims to improve the focus, care, and resources available to organ donors, recipients, and caregivers. The success of the new system depends on its flawless implementation and the establishment of patient-centric goals to measure progress and improve system performance. Key areas for success include seamless collaboration between participating organizations, leveraging data and artificial intelligence (AI), governance based on transparency, and overcommunication with the community. The modernization of the organ transplant system is an opportunity to utilize data analytics and reporting, establish a public-private partnership, and gain support and resources from the U.S. Department of Health and Human Services (HHS) to improve outcomes and save lives.