A recent case report published in Cureus highlights the occurrence of iatrogenic amyloid polyneuropathy following a domino liver transplantation. The case involved a patient who underwent liver transplantation involving a donor with familial amyloid polyneuropathy (FAP). Iatrogenic amyloid polyneuropathy refers to the development of amyloidosis, a condition characterized by abnormal protein deposits, following a medical intervention.
The patient in question displayed symptoms of amyloid polyneuropathy one year after the liver transplantation. These symptoms included weakness, numbness, and tingling in the limbs. Further investigation confirmed the presence of amyloid deposits in the peripheral nerves. This case signifies the importance of considering the possibility of iatrogenic amyloid polyneuropathy in patients who have undergone organ transplantation from donors with FAP.
Although the occurrence of iatrogenic amyloid polyneuropathy following organ transplantation is rare, this case highlights the potential risks associated with such procedures. It emphasizes the need for thorough screening and evaluation of donors to minimize the chances of transmitting inheritable diseases. Additionally, it underscores the importance of monitoring transplant recipients for potential complications post-surgery. Further research is warranted to gain a better understanding of the factors that contribute to the development of iatrogenic amyloid polyneuropathy and to develop preventive measures.
